https://www.nature.com/articles/s42003-022-03991-9
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Cryo-EM structure-based selection of computed ligand poses enables design of MTA-synergic PRMT5 inhibitors of better potency | Communications Biology - Nature.com
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10/3/22 at 8:26pm
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Science Health PRMT5 MTA ligand poses Cryo-EM drug design
Cryo-EM map-guided drug design and computational comparison of ligand poses yield a PRMT5 inhibitor or derivatives that are MTA-synergic and show enhanced potency.
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