https://www.nature.com/articles/s42003-023-04412-1
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Unraveling topoisomerase IA gate dynamics in presence of PPEF and its preclinical evaluation against multidrug-resistant pathogens | Communications Biology - Nature.com
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2/18/23 at 5:38am
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Science Infectious Diseases PPEF topoisomerase gate dynamics IA DNA cleavage TopoIA Communications Biology - Nature.com Two topoisomerase I enzymes BPVF DNA binding
Two potent inhibitors PPEF and BPVF of bacterial TopoIA enzymes function by impairing DNA binding and thus DNA cleavage and relaxation activities of bacterial topoisomerase I enzymes.
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