https://virologyj.biomedcentral.com/articles/10.1186/s12985-023-02154-4
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Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron - Virology Journal - Virology Journal
11/8/23 at 4:10pm
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Health Biological Sciences fitness changes E484 SARS-CoV E484A Omicron - Virology Journal - Virology Journal Background Intrinsic anti-SARS-CoV-2
Background Intrinsic fitness costs are likely to have guided the selection of lineage-determining mutations during emergence of variants of SARS-CoV-2. Whereas changes in receptor affinity and antibody neutralization have been thoroughly mapped for individual…
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